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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: O43707




USC-OGP 2-DE database:  O43707


O43707


General information about the entry
View entry in simple text format
Entry nameACTN4_HUMAN
Primary accession numberO43707
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Alpha-actinin-4 {ECO:0000305}; AltName: Full=Non-muscle alpha-actinin 4 {ECO:0000303|PubMed:10656685};.
Gene nameName=ACTN4 {ECO:0000312|HGNC:HGNC:166}
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.91; Mw=122096
pI=5.37; Mw=117553
pI=5.51; Mw=115893
pI=5.13; Mw=16684

Cross-references
UniProtKB/Swiss-ProtO43707; ACTN4_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameACTN4_HUMAN
Primary accession numberO43707
Secondary accession number(s) A4K467 D6PXK4 O76048
Sequence was last modified on February 21, 2001 (version 2)
Annotations were last modified on March 15, 2017 (version 200)
Name and origin of the protein
DescriptionRecName: Full=Alpha-actinin-4 {ECO:0000305}; AltName: Full=Non-muscle alpha-actinin 4 {ECO:0000303|PubMed:10656685};
Gene nameName=ACTN4 {ECO:0000312|HGNC:HGNC:166}
Encoded onName=ACTN4 {ECO:0000312|HGNC:HGNC:166
Keywords3D-structure; Acetylation; Actin-binding; Alternative splicing; Calcium; Cell junction; Complete proteome; Cytoplasm; Disease mutation; Metal-binding; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLU48734; AAC17470.1; ALT_FRAME; mRNA
EMBLGU987085; ADG03678.1; -; mRNA
EMBLDQ431186; ABD96103.1; -; mRNA
EMBLAC008649; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAC022144; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC005033; AAH05033.1; -; mRNA
EMBLAL047603; -; NOT_ANNOTATED_CDS; mRNA
EMBLAU118403; -; NOT_ANNOTATED_CDS; mRNA
EMBLD89980; BAA24447.1; ALT_INIT; mRNA
CCDSCCDS12518.1; -. [O43707-1]; .
RefSeqNP_004915.2; NM_004924.5. [O43707-1]; .
UniGeneHs.270291; -; .
PDB1WLX; NMR; -; A=519-645
PDB1YDI; X-ray; 1.80 A; B=734-757
PDB2R0O; X-ray; 2.20 A; A/B=47-271
PDBsum1WLX; -; .
PDBsum1YDI; -; .
PDBsum2R0O; -; .
ProteinModelPortalO43707; -; .
SMRO43707; -; .
BioGrid106596; 122; .
DIPDIP-33179N; -; .
IntActO43707; 83; .
MINTMINT-4998602; -; .
STRING9606.ENSP00000252699; -; .
iPTMnetO43707; -; .
PhosphoSitePlusO43707; -; .
SwissPalmO43707; -; .
BioMutaACTN4; -; .
REPRODUCTION-2DPAGEO43707; -; .
EPDO43707; -; .
MaxQBO43707; -; .
PaxDbO43707; -; .
PeptideAtlasO43707; -; .
PRIDEO43707; -; .
DNASU81; -; .
EnsemblENST00000252699; ENSP00000252699; ENSG00000130402. [O43707-1]; .
EnsemblENST00000390009; ENSP00000439497; ENSG00000130402. [O43707-2]; .
EnsemblENST00000634692; ENSP00000488962; ENSG00000282844. [O43707-2]; .
EnsemblENST00000634960; ENSP00000489220; ENSG00000282844. [O43707-1]; .
GeneID81; -; .
KEGGhsa:81; -; .
UCSCuc002oja.3; human. [O43707-1]; .
CTD81; -; .
DisGeNET81; -; .
GeneCardsACTN4; -; .
HGNCHGNC:166; ACTN4; .
HPAHPA001873; -; .
HPAHPA006035; -; .
MalaCardsACTN4; -; .
MIM603278; phenotype; .
MIM604638; gene; .
neXtProtNX_O43707; -; .
OpenTargetsENSG00000130402; -; .
Orphanet93213; Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis; .
PharmGKBPA23; -; .
eggNOGKOG0035; Eukaryota; .
eggNOGCOG5069; LUCA; .
GeneTreeENSGT00760000118813; -; .
HOGENOMHOG000263418; -; .
HOVERGENHBG050453; -; .
InParanoidO43707; -; .
KOK05699; -; .
OMAKQRDYET; -; .
OrthoDBEOG091G020R; -; .
PhylomeDBO43707; -; .
TreeFamTF352676; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
ReactomeR-HSA-373753; Nephrin interactions; .
SIGNORO43707; -; .
ChiTaRSACTN4; human; .
EvolutionaryTraceO43707; -; .
GeneWikiActinin_alpha_4; -; .
GenomeRNAi81; -; .
PMAP-CutDBO43707; -; .
PROPR:O43707; -; .
ProteomesUP000005640; Chromosome 19; .
BgeeENSG00000130402; -; .
CleanExHS_ACTN4; -; .
ExpressionAtlasO43707; baseline and differential; .
GenevisibleO43707; HS; .
GOGO:0005903; C:brush border; IEA:Ensembl; .
GOGO:0005911; C:cell-cell junction; IEA:Ensembl; .
GOGO:0030863; C:cortical cytoskeleton; IEA:Ensembl; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:HPA; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0005622; C:intracellular; IDA:UniProtKB; .
GOGO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; .
GOGO:0043005; C:neuron projection; IEA:Ensembl; .
GOGO:0016604; C:nuclear body; IDA:HPA; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0043234; C:protein complex; IDA:UniProtKB; .
GOGO:0031143; C:pseudopodium; TAS:UniProtKB; .
GOGO:0001725; C:stress fiber; IEA:Ensembl; .
GOGO:0030018; C:Z disc; IEA:Ensembl; .
GOGO:0003779; F:actin binding; TAS:UniProtKB; .
GOGO:0051015; F:actin filament binding; IDA:UniProtKB; .
GOGO:0005509; F:calcium ion binding; IEA:InterPro; .
GOGO:0031490; F:chromatin DNA binding; IDA:UniProtKB; .
GOGO:0005178; F:integrin binding; TAS:UniProtKB; .
GOGO:0044325; F:ion channel binding; IPI:UniProtKB; .
GOGO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IMP:UniProtKB; .
GOGO:0035257; F:nuclear hormone receptor binding; IPI:UniProtKB; .
GOGO:0001882; F:nucleoside binding; IDA:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IPI:UniProtKB; .
GOGO:0042974; F:retinoic acid receptor binding; IPI:UniProtKB; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:UniProtKB; .
GOGO:0051017; P:actin filament bundle assembly; IEA:Ensembl; .
GOGO:0070830; P:bicellular tight junction assembly; IEA:Ensembl; .
GOGO:0051271; P:negative regulation of cellular component movement; IEA:Ensembl; .
GOGO:1900025; P:negative regulation of substrate adhesion-dependent cell spreading; IMP:UniProtKB; .
GOGO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IDA:UniProtKB; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0030335; P:positive regulation of cell migration; IMP:UniProtKB; .
GOGO:0051272; P:positive regulation of cellular component movement; IDA:UniProtKB; .
GOGO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IMP:UniProtKB; .
GOGO:0048549; P:positive regulation of pinocytosis; IEA:Ensembl; .
GOGO:0032417; P:positive regulation of sodium:proton antiporter activity; NAS:UniProtKB; .
GOGO:1902396; P:protein localization to bicellular tight junction; IEA:Ensembl; .
GOGO:0015031; P:protein transport; IEA:UniProtKB-KW; .
GOGO:0042981; P:regulation of apoptotic process; NAS:UniProtKB; .
GOGO:1903506; P:regulation of nucleic acid-templated transcription; IMP:UniProtKB; .
GOGO:0001666; P:response to hypoxia; IEA:Ensembl; .
GOGO:0048384; P:retinoic acid receptor signaling pathway; IDA:UniProtKB; .
GOGO:0030050; P:vesicle transport along actin filament; IMP:UniProtKB; .
CDDcd00014; CH; 2; .
CDDcd00051; EFh; 1; .
Gene3D1.10.238.10; -; 2; .
Gene3D1.10.418.10; -; 2; .
InterProIPR001589; Actinin_actin-bd_CS; .
InterProIPR001715; CH-domain; .
InterProIPR011992; EF-hand-dom_pair; .
InterProIPR014837; EF-hand_Ca_insen; .
InterProIPR018247; EF_Hand_1_Ca_BS; .
InterProIPR002048; EF_hand_dom; .
InterProIPR018159; Spectrin/alpha-actinin; .
InterProIPR002017; Spectrin_repeat; .
PfamPF00307; CH; 2; .
PfamPF08726; EFhand_Ca_insen; 1; .
PfamPF00435; Spectrin; 4; .
SMARTSM00033; CH; 2; .
SMARTSM00054; EFh; 2; .
SMARTSM00150; SPEC; 4; .
SUPFAMSSF47473; SSF47473; 1; .
SUPFAMSSF47576; SSF47576; 1; .
PROSITEPS00019; ACTININ_1; 1; .
PROSITEPS00020; ACTININ_2; 1; .
PROSITEPS50021; CH; 2; .
PROSITEPS00018; EF_HAND_1; 1; .
PROSITEPS50222; EF_HAND_2; 2; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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